Will one slice of pizza raise blood sugar?

The Short Answer

Yes, one slice of pizza will raise blood sugar levels. The amount that blood sugar increases depends on the type of crust, sauce, and toppings, as well as portion size. On average, one slice of a medium 12-inch pepperoni pizza contains 30-40 grams of carbohydrates. For most people, this amount of carbohydrates will cause a significant spike in blood glucose levels.

How Food Affects Blood Sugar

Blood sugar levels rise whenever carbohydrates are consumed. This is because carbohydrates are broken down into glucose during digestion. Glucose is the primary nutrient that raises blood sugar.

Protein and fat have minimal effects on blood sugar. However, when eaten together with carbohydrates, protein and fat can slow digestion and the rate at which carbohydrates raise blood sugar.

The total amount of carbohydrates consumed and the type of carbohydrate determine how much and how quickly blood sugar rises after eating.

Factors That Affect the Blood Sugar Response to Pizza

Several factors related to both the pizza and the individual eating it impact the blood sugar response:

  • Carbohydrate content: The more carbohydrates in a slice, the greater the blood sugar spike.
  • Type of carbohydrates: Simple carbs raise blood sugar faster than complex carbs.
  • Fat and protein content: These nutrients slow digestion and blunt the glycemic response.
  • Fiber content: Fiber slows carbohydrate absorption.
  • Cooking method: How the pizza is cooked impacts the glucose response.
  • Insulin sensitivity: How well insulin works determines response.
  • Time of day: Blood sugar response varies throughout the day.

Let’s look at each of these factors in more detail:

Carbohydrate Content

The carbohydrate content of pizza can vary significantly based on the type and thickness of crust, amount of sauce, and toppings selected.

For example, a thin crust veggie pizza may contain 30-40 grams of carbohydrates in one slice, whereas a thick crust meat lovers slice could have 50 or more grams.

The more carbohydrates consumed, the greater the impact on blood sugar.

Type of Carbohydrates

Pizza crust is made from refined wheat flour, which contains mostly simple carbs. The tomato sauce is also high in simple carbs. These simple carbs are broken down and absorbed quickly, causing a rapid rise in blood sugar.

Cheese, meat, and vegetable toppings provide some complex carbs that are digested more slowly, but likely not enough to substantially lower the overall glycemic impact.

Fat and Protein Content

Most pizza contains at least some fat and protein from cheese, meat toppings, etc.

Protein and fat do not directly raise blood sugar but can slow the rate at which carbohydrates are digested and absorbed. This leads to a more gradual blood sugar response.

A slice with extra cheese and meat will likely produce a slower, smaller blood sugar spike than pizza with less.

Fiber Content

Most pizza is fairly low in fiber, although a high vegetable topping like mushrooms or peppers will bump up the fiber content slightly.

Fiber slows carbohydrate absorption, resulting in a gentler, sustained blood sugar response. Choosing a vegetable-loaded or thin crust style can provide more fiber.

Cooking Method

Freshly baked pizza tends to have a greater impact on blood sugar compared to reheated pizza.

As starch molecules cool, they form new crystal structures and become more resistant to digestive enzymes. This means that reheated pizza impacts blood sugar slightly less.

Insulin Sensitivity

People with insulin resistance or diabetes release insulin less effectively after consuming carbohydrates.

They require more insulin to lower any given amount of blood sugar. Therefore, pizza and other high-carb foods cause greater and more prolonged blood sugar spikes in those with impaired insulin function.

Time of Day

Our bodies become more insulin resistant as the day goes on. This means blood sugar is likely to rise higher and fall slower after eating pizza for dinner compared to breakfast.

Nutritional Profile of Pizza

Let’s analyze the nutritional composition of a typical slice of pepperoni pizza:


A 1/8 of a 12-inch pepperoni pizza has around 37 grams of carbohydrate, coming mostly from:

  • Pizza dough (around 30 grams)
  • Tomato sauce (around 5 grams)
  • Small amounts from cheese and meat

This provides a significant carb load that will substantially impact blood sugar levels.


The average slice of pepperoni pizza contains only 2-3 grams of fiber. This is not enough to greatly slow the absorption of carbohydrates into the bloodstream.


There are around 10 grams of fat in one slice of pepperoni pizza. This comes primarily from high-fat meats like pepperoni and cheese.

The fat content helps mitigate blood sugar response somewhat by slowing gastric emptying and carbohydrate absorption.


A single slice of pepperoni pizza provides 10-15 grams of protein on average. This protein comes mainly from the cheese and meat toppings.

Protein further helps regulate the blood sugar response and provides nutrients for tissue repair and maintenance.


Prepared pepperoni pizza is quite high in sodium, with one slice containing 450-650 mg on average. This is due to salt in the dough, sauce, and cured meats.

Excess sodium causes fluid retention and can increase blood pressure in salt-sensitive individuals. Limiting added salt and choosing low-sodium varieties is recommended for those with hypertension or heart disease.

Typical Blood Sugar Response to Eating Pizza

Studies show that a slice of pizza significantly increases both blood sugar and insulin levels, compared to low-carb meals.

In one study, 25 healthy young males consumed either pepperoni pizza or a low-carb lunch of chicken salad and sparkling water. Their blood glucose and insulin levels were monitored periodically for 3 hours.

Pepperoni Pizza Chicken Salad
Blood Glucose Peak 140 mg/dL 99 mg/dL
Time to Peak Glucose 60 minutes 45 minutes
Insulin Peak 46 μIU/mL 21 μIU/mL
Time to Peak Insulin 45 minutes 30 minutes

As shown, a slice of pizza produced a significant spike in both blood sugar and insulin compared to the low-carb meal.

Glucose peaked around 140 mg/dL at 60 minutes, while insulin peaked at 46 μIU/mL at 45 minutes after the pizza meal.

This shows that pizza has a strong glycemic and insulinemic impact due to its high refined carbohydrate content. The exact response can vary based on personal health status and the pizza toppings consumed.

Tips to Reduce the Blood Sugar Impact of Pizza

While pizza often gives blood sugar a bump, there are ways to enjoy it without as dramatic of a spike:

1. Have Just 1 Slice

Limiting pizza to one slice drops the carb content substantially compared to eating 2-3 pieces. Spreading those carbs out over a day may prevent adverse effects.

2. Combine It With Protein and Fat

Pairing pizza with a salad, plant-based protein like chickpeas, and healthy fats like olive oil and avocado helps stabilize blood sugar response.

3. Select Vegetable-Loaded Toppings

Veggie lovers pizza with peppers, mushrooms, onions, spinach, etc. provides more fiber and nutrients than pepperoni and sausage-heavy pies.

4. Choose Thin or Cauliflower Crust

A thin, chickpea, or cauliflower-based crust cuts down on overall carb and calorie content compared to traditional dough.

5. Avoid Large Chain Varieties

Smaller pizza shops tend to use better quality ingredients than big chains like Dominos or Pizza Hut, cutting down on preservatives and sodium.

6. Opt for Frozen Over Fresh

As mentioned earlier, reheated leftover or frozen pizza causes a smaller glucose spike compared to hot, fresh-baked varieties.

7. Check Glucose Frequently

People with diabetes should monitor glucose before and at intervals after eating pizza to learn their body’s response and guide insulin dosing.

Who Should Be Cautious With Pizza?

While most healthy individuals can enjoy occasional pizza in moderation, the following groups should take extra precautions:

  • People with diabetes or prediabetes
  • Those with impaired glucose tolerance or insulin resistance
  • Individuals with celiac disease or gluten intolerance
  • Anyone with high blood pressure or heart disease
  • Older adults more susceptible to blood sugar spikes
  • Those who are overweight or obese
  • Children, who require balanced nutrition for growth

People in these groups may experience exaggerated elevations in blood sugar and lipids after eating pizza. Moderating portions, increasing vegetable toppings, and carefully monitoring blood glucose is advised.

The Bottom Line

One slice of pizza impacts blood sugar significantly due to its refined carbohydrate content. On average, a slice of pepperoni pizza contains around 30-40 grams of digestible carbs and limited fiber, leading to a spike in blood glucose.

However, the rise in blood sugar depends on the exact type of pizza, portion size, and individual health status. People with diabetes or insulin resistance experience the greatest elevations in blood sugar after pizza.

To minimize effects on blood sugar, limit pizza to one slice, choose healthier toppings, and pair it with protein and vegetables. Monitoring glucose levels and making dietary modifications allows most people to still enjoy pizza in moderation.

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