Is it OK to drink Pedialyte after 48 hours?

Pedialyte is an oral rehydration solution that is commonly used to prevent or treat dehydration in infants, children, and adults. It helps replace fluids, electrolytes, and nutrients lost due to vomiting, diarrhea, fever, or sweat. While Pedialyte is safe for most people, there are some things to consider regarding how long it can be used after opening.

Quick Answers

Pedialyte can typically be used for up to 48 hours after opening. However, there are a few factors that determine how long it remains safe and effective to drink:

  • Storage conditions – Keeping Pedialyte refrigerated and tightly sealed can help it last longer.
  • Expiration date – The expiration date on the package should still be valid.
  • Color/smell – Clear color and normal smell indicate it is still fresh.
  • Purpose – Using Pedialyte as a preventative measure allows more time than treating severe dehydration.

If there are any signs of spoilage, it is best to discard Pedialyte after 48 hours. For severely dehydrated individuals, fresh Pedialyte is recommended. Otherwise, it can be safely consumed within 2 days of opening if properly stored.

Does Pedialyte Expire After Opening?

Pedialyte itself does not technically expire or go bad immediately after opening. An unopened, sealed bottle of Pedialyte will typically have an expiration date printed on the label that is 18-24 months from the manufacturing date. However, once opened, the shelf life becomes much shorter.

This is because Pedialyte is formulated as a sterile solution. When the sealed bottle is opened for the first time, it becomes exposed to microbes in the air and environment. The ingredients in Pedialyte also begin deteriorating through exposure to oxygen, light, and warmer temperatures.

For food safety purposes, opened Pedialyte should not be used beyond the manufacturer’s recommended timeframe. This is usually 24-48 hours after opening.

Pedialyte Ingredients and Shelf Life

Pedialyte contains water, dextrose, citric acid, natural flavors, salt and zinc sulfate. The combination of ingredients makes it ideal for rehydration, but also means it can spoil once exposed to air:

  • Dextrose – This sugar helps absorb water and sodium in the intestines. In solution, it can support microbial growth.
  • Citric acid – Used as a flavoring and preservative, but begins degrading with light exposure.
  • Natural flavors – Spoil over time with oxidation.
  • Zinc sulfate – Added for immune support but breaks down without refrigeration.

The initial sterile filtration and bottling of Pedialyte gives it a long shelf life unopened. But once exposed to air, its nutrients and therapeutic properties begin to degrade. Refrigeration and timely usage helps lengthen the opened shelf life.

How Long Does Pedialyte Last After Opening?

The manufacturer recommends consuming Pedialyte within 24-48 hours after opening. This short window is due to the potential for bacterial growth and breakdown of the active ingredients. However, there are some steps you can take to safely prolong the shelf life of opened Pedialyte:

  • Refrigerate after opening – Keeping Pedialyte chilled in the fridge slows bacteria growth and preserves the nutrients.
  • Keep tightly sealed – Minimize exposure to air and contamination by sealing the bottle firmly.
  • Avoid extreme temperatures – Do not store Pedialyte anywhere that gets hotter than room temperature.
  • Check for changes – Discard if you notice any changes in smell, taste, or consistency.
  • Use quickly once dehydrated – When treating dehydration, use freshly opened Pedialyte.

Following these tips, an opened bottle of Pedialyte can often last up to 48 hours in the refrigerator. However, it’s best to discard any leftovers after this time, even if refrigerated. The nutrients begin degrading and bacteria may start growing, making it unsafe to drink.

Can I Drink Pedialyte After 48 Hours?

Drinking Pedialyte more than 48 hours after opening is not recommended. The risk of bacterial contamination and degradation of the Pedialyte solution increases over time. Consuming bad Pedialyte can actually do more harm than good at this point.

After 48 hours, any remaining Pedialyte should be discarded. The exception would be if it was stored continuously refrigerated and the bottle has remained completely sealed. Even then, inspect it closely for any changes in appearance, consistency, or smell before drinking.

If you are treating severe dehydration, doctors actually recommend only drinking Pedialyte that has been newly opened. Using previously opened Pedialyte that has been stored for more than 24 hours is not ideal when rehydrating. The electrolyte concentrations and therapeutic effect may be reduced.

How to Tell If Pedialyte Has Gone Bad

There are a few key signs that indicate opened Pedialyte is no longer safe or effective to drink:

  • Change in color – It should maintain a clear, pale yellow hue. Any darkening may indicate contamination.
  • Cloudiness – The liquid should be completely transparent with no murkiness.
  • Change in smell – An overly sweet, sour, or rotten odor is a red flag.
  • Fizzing or bubbling – This can indicate fermentation and carbon dioxide production from bacteria.
  • Mold – Check bottle caps and seals for any fuzzy mold growth.

If Pedialyte exhibits any of these characteristics or just smells or tastes “off,” you should discard it rather than take the risk of drinking spoiled product. Remember, always inspect Pedialyte before use if it has been opened for longer than 48 hours.

How to Store Opened Pedialyte

To get the longest shelf life out of opened Pedialyte, proper storage is key:

  • Refrigerate promptly – As soon as Pedialyte is opened, store it in the refrigerator.
  • Seal the bottle – Replace cap tightly to prevent contamination and slow oxidation.
  • Use clean utensils – Always use a clean cup and avoid dipping dirty utensils back into the bottle.
  • Don’t mix with formula – Don’t mix leftover Pedialyte with infant formula, it shortens its shelf life.
  • Limit temperature fluctuations – Avoid leaving it sitting out too long or heating up once opened.

Following these precautions creates the best conditions for minimizing microbial growth and deterioration. Refrigeration is most critical, as the cool temperature drastically slows the rate of spoilage.

Does Pedialyte Lose Effectiveness Over Time?

Yes, Pedialyte can begin losing effectiveness and therapeutic benefit the longer it is opened and stored. There are two main reasons for this:

  1. Degraded ingredients – The preservatives, electrolytes, and other nutrients in Pedialyte break down over time with exposure to air and warmer temperatures.
  2. Lower concentrations – Water can evaporate from opened Pedialyte stored at room temperature, increasing concentration of ingredients.

Both of these factors mean that Pedialyte that has been opened for more than 24-48 hours may not provide the same rehydrating and electrolyte replenishing effects compared to fresh Pedialyte.

How Potency is Reduced

More specifically, here is how the major ingredients in Pedialyte lose effectiveness after opening:

  • Dextrose – Sugars support rehydration but degrade over time and can feed microbes.
  • Sodium & potassium – These critical electrolytes begin oxidizing in solution.
  • Zinc – Breaks down without refrigeration and proper sealing.
  • Citric acid – Flavoring and preservative effects diminish with exposure.
  • Water – Evaporates causing improper concentrations.

Testing has shown that Pedialyte can lose up to 30% of its electrolyte content if left opened at room temperature for 48 hours. Refrigeration helps slow this nutrient breakdown significantly.

When Fresh Pedialyte is Needed

For treating mild dehydration, opened Pedialyte stored properly for 24-48 hours may still provide adequate rehydration. However, in certain situations fresh Pedialyte is strongly recommended:

  • Moderate to severe dehydration
  • High fluid losses from extreme vomiting or diarrhea
  • Infants under 6 months old
  • High fever or illness in children

The reduced potency and concentration changes in older opened Pedialyte may not be sufficient. Doctors advise using only newly opened Pedialyte for these patients requiring urgent rehydration.

Pedialyte for Preventing Dehydration

Pedialyte can also be used to prevent dehydration before symptoms start. This may include:

  • Pediatric illnesses with fluid loss risk
  • Before/after surgery
  • Vigorous exercise causing heavy sweating
  • Traveling in hot climates

For preventative use, opened Pedialyte can often last up to 48 hours if refrigerated and the bottle is kept sealed. The lower levels of electrolytes and nutrients may still be enough to help maintain good hydration.

How Long Does Pedialyte Last For Prevention?

The shelf life of opened Pedialyte solely for preventative hydration depends on storage but can extend up to:

  • 24 hours at room temperature – Sealed bottle.
  • 48 hours refrigerated – Optimal storage to maximize shelf life.
  • 5-7 days refrigerated – If absolutely no signs of spoilage and bottle has stayed fully sealed.

Medical experts caution against using opened Pedialyte for longer than 2 days even if refrigerated. Check for changes in smell or appearance before use.

Risks of Old Pedialyte for Prevention

Although the risks are lower, it is still possible for older opened Pedialyte used as prevention to cause problems. This includes:

  • Gastrointestinal symptoms if bacteria is present
  • Inadequate hydration and electrolyte levels
  • Unpleasant taste
  • Potential allergic reaction in sensitive individuals

To avoid issues, refrigerate opened Pedialyte immediately after use and discard any remainder after 48 hours. Only drink what is needed for prevention and treat any illnesses with fresh product.


Does Pedialyte need to be refrigerated after opening?

Yes, you should refrigerate Pedialyte immediately after opening. Refrigeration is key for maintaining the safety and extending the shelf life of Pedialyte once the bottle is opened. The cool temperature slows bacteria growth and preserves the ingredient potency.

Can I freeze leftover Pedialyte?

No, you should not freeze extra Pedialyte. Freezing can damage the chemical structure of the Pedialyte solution. This alters its therapeutic effects. Also, contaminants present before freezing may not be killed off by the freezing process.

Is it safe to use Pedialyte after expiration date?

No, you should not use Pedialyte after the expiration date printed on the bottle. Manufacturers choose expiration dates to ensure the product is only used when it is within peak quality and safety parameters. An expired medical solution like Pedialyte poses unacceptable risks.

Does Pedialyte need to be used within 24 hours?

According to manufacturer guidelines, Pedialyte does need to be used within 24 hours after opening for vulnerable populations like infants and the severely dehydrated. Maximum safety and effects are retained for 24-48 hours if refrigerated. General preventative use allows up to 48 hours after opening if kept refrigerated and sealed.

Can I mix formula with Pedialyte?

No, you should avoid mixing leftover Pedialyte with infant formula. The Pedialyte will dilute the nutritional formulation. It can also contaminate the formula, significantly reducing how long the mixed product can be safely stored.


In most cases, Pedialyte can be safely consumed within 48 hours of opening if it has been stored properly in the refrigerator in a sealed container. This allows time for both treating and preventing dehydration. However, Pedialyte should always be inspected before use for any signs of spoilage.

After 48 hours, opened Pedialyte needs to be discarded as degradation starts impacting its effectiveness and bacterial contamination risks increase. When treating severe dehydration, only newly opened Pedialyte is recommended for optimal results. But general preventative use can often allow up to 2 days if refrigerated and the bottle remains well-sealed.

By understanding how long Pedialyte lasts after opening and taking steps to properly store it, you can safely retain its therapeutic benefits while avoiding potential health risks. Be sure to inspect for signs of spoilage, follow manufacturer guidelines for shelf life, and stick to the 48 hour window for optimal quality and performance.

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