How much 25mg Benadryl can I give my dog?

Benadryl (diphenhydramine) can be used in dogs for treating allergies, travel anxiety, and other conditions. However, it’s important to consult with your veterinarian before giving Benadryl or any medication to your pet. Your vet will be able to determine the appropriate dosage for your specific dog based on factors like weight, medical history, and the condition being treated.

Key Points

  • Always consult your vet before giving Benadryl or any medication to your dog
  • Benadryl dosage for dogs is based on the dog’s weight
  • Start with a low dosage and monitor your dog’s response
  • Too much Benadryl can cause sedation, fast heart rate, and other side effects
  • Never give your dog medications made for humans without vet approval

Benadryl Dosage for Dogs

The general dosage guidelines for giving Benadryl to dogs are:

  • 1 mg per pound of body weight, given 2-3 times a day
  • Dose may be rounded down to the nearest measurable amount
  • For a 25 mg tablet, a 25 pound dog would get one tablet twice a day

However, there are some important things to keep in mind:

  • Always start with the lowest effective dose
  • Never exceed the maximum dosage of 3 mg per pound daily
  • Dogs with liver or kidney disease may need a reduced dosage
  • Puppies and small breeds need an even smaller dose

That’s why it’s so important to talk to your vet first to determine the ideal Benadryl dose for your individual dog.

Benadryl Side Effects in Dogs

Potential side effects of Benadryl in dogs include:

  • Sedation or drowsiness
  • Dry mouth
  • Urinary retention
  • Rapid heart rate
  • Constipation
  • Confusion or disorientation
  • Hyperactivity (rare)

Very high doses can cause severe reactions like seizures, coma, and death. Mild side effects like sedation are more common. Monitor your dog closely for any side effects after giving Benadryl.

Alternatives to Benadryl

Some alternatives to Benadryl for dogs include:

  • Diphenhydramine (generic Benadryl) – capsules can be opened and contents mixed with food
  • Cetirizine (Zyrtec) – less sedating than Benadryl
  • Loratadine (Claritin) – non-sedating, longer lasting than Benadryl
  • Hydroxyzine – antihistamine, also used for anxiety
  • Apoquel – specifically treats dog allergies and itching

Talk to your vet about the best medication options for your dog’s specific needs. Never give your dog any medication without veterinary guidance.


While Benadryl can be safe for dogs when used correctly under veterinary supervision, it’s imperative to get dosage recommendations from your vet before administering it. Never exceed the maximum safe dosage based on your dog’s weight. Carefully monitor for side effects like sedation or hyperactivity. Your vet can recommend safer antihistamine alternatives if Benadryl isn’t well tolerated.

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